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Johnson & Johnson Acquires Intra-Cellular Therapies for $14.6 Billion, Expanding Mental Health Portfolio

In a significant move that reshapes the landscape of mental health therapeutics, Johnson & Johnson (NYSE: JNJ) announced today its acquisition of Intra-Cellular Therapies (NASDAQ: ITCI) for $14.6 billion, or $132.00 per share in cash. The deal marks J&J’s strategic expansion into the neuroscience sector and strengthens its position in the treatment of mental health disorders.

The centerpiece of this acquisition is CAPLYTA® (lumateperone), Intra-Cellular’s flagship drug that has already secured FDA approval for treating bipolar I and II depression and schizophrenia in adults. The medication has demonstrated remarkable potential, with analysts projecting peak year sales exceeding $5 billion. This acquisition comes at a crucial time as CAPLYTA® is currently under FDA review for adjunctive treatment in major depressive disorder (MDD), following successful Phase 3 trials that showed statistically significant improvement in depressive symptoms.

Joaquin Duato, Chairman and CEO of Johnson & Johnson, emphasized the strategic importance of this acquisition, stating that it builds upon their 70-year legacy in neuroscience and demonstrates their commitment to advancing research in neuropsychiatric and neurodegenerative disorders. The deal not only includes CAPLYTA® but also brings ITI-1284, a promising Phase 2 compound being studied for generalized anxiety disorder and Alzheimer’s disease-related conditions.

The timing of this acquisition appears particularly strategic, as Intra-Cellular Therapies recently reached a settlement agreement with Sandoz Inc. regarding patent litigation for CAPLYTA®, securing market exclusivity until July 1, 2040. This agreement strengthens the long-term value proposition of the acquisition for Johnson & Johnson.

Prior to the acquisition announcement, Intra-Cellular Therapies had been showing strong market performance, with its stock reaching an all-time high of $93.57. The company’s robust financial health was evident in its Q3 2024 performance, with CAPLYTA® achieving net product sales that led to an increased 2024 guidance range of $665 to $685 million.

The transaction, expected to close later in 2025, is subject to regulatory approvals and ITCI stockholder approval. Johnson & Johnson plans to finance the acquisition through a combination of cash and debt while maintaining its capital allocation priorities. The deal represents a 39% premium to Intra-Cellular’s closing price before the announcement.

This acquisition is part of J&J’s broader strategy to drive growth beyond 2025, particularly as it faces potential competition for its psoriasis drug Stelara. The company has been actively pursuing strategic acquisitions, including recent deals with Numab, Proteologix, and Shockwave Medical.

The merger brings together Johnson & Johnson’s extensive resources and global reach with Intra-Cellular’s innovative approach to mental health treatment. Dr. Sharon Mates, Chairman and CEO of Intra-Cellular Therapies, expressed enthusiasm about the merger, highlighting the potential to reach more patients worldwide through J&J’s established presence in the pharmaceutical industry.

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